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D-SPIN constructs regulatory network models from scRNA-seq that reveal organizing principles of perturbation response Permalink
Published in Cell, 2026
D-SPIN builds quantitative, interpretable gene regulatory network models from large-scale single-cell perturbation datasets. The framework reveals key regulators of cell-state decisions and organizing principles of cellular responses to genetic and drug perturbations.
Recommended citation: Jiang, J., Chen, S., Tsou, T., McGinnis, C. S., Khazaei, T., Zhu, Q., Park, J. H., Strazhnik, I.-M., Vielmetter, J., Gong, Y., Hanna, J., Chow, E. D., Sivak, D. A., Gartner, Z. J., & Thomson, M. (2026). "D-SPIN constructs regulatory network models from scRNA-seq that reveal organizing principles of perturbation response." Cell, 189(13), 4159–4184.e35. https://doi.org/10.1016/j.cell.2026.04.028 https://www.cell.com/cell/fulltext/S0092-8674(26)00463-0