Tunable population diversity through a noise-driven differentiation switch
Published in bioRxiv (preprint), 2026
Recommended citation: Jiang, J., Chen, S., Park, J. H., Tsou, T., Yang, V., Rivaud, P., & Thomson, M. (2026). "Tunable population diversity through a noise-driven differentiation switch." bioRxiv [Preprint], version 3. https://doi.org/10.1101/2025.09.20.677552 https://www.biorxiv.org/content/10.1101/2025.09.20.677552v3.full
Single-cell RNA sequencing across 40 signaling conditions and D-SPIN regulatory network models reveal how combinations of signals tune the proportions of neurons and glia. The study identifies a candidate noise-driven differentiation switch that links transcriptional variability to probabilistic cell-fate decisions.
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