Selected publications

Graphical abstract showing how D-SPIN infers regulatory networks and cell-state responses from single-cell perturbation data

D-SPIN constructs regulatory network models from scRNA-seq that reveal organizing principles of perturbation response

Jialong Jiang, Sisi Chen, Tiffany Tsou, Christopher S. McGinnis, Tahmineh Khazaei, Qin Zhu, Jong H. Park, Inna-Marie Strazhnik, Jost Vielmetter, Yingying Gong, John Hanna, Eric D. Chow, David A. Sivak, Zev J. Gartner, and Matt Thomson

Cell 189(13), 4159–4184.e35 (2026).

Figure 1: signaling inputs tune neural progenitor differentiation into neurons and glia through a noise-driven regulatory switch

Tunable population diversity through a noise-driven differentiation switch

Jialong Jiang, Sisi Chen, Jong H. Park, Tiffany Tsou, Vickie Yang, Paul Rivaud, and Matt Thomson

bioRxiv (preprint) (2026).